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Placebo-controlled trials indicate that Cytisine, a partial agonist that binds the nicotinic acetylcholine receptor and is used for smoking cessation, almost doubles the chances of quitting at 6 month ...


Antipsychotics and mood stabilisers are prescribed widely to patients with psychiatric disorders worldwide. Despite clear evidence for their efficacy in relapse prevention and symptom relief, their ef ...


Few pharmacotherapies have demonstrated sufficient efficacy in the treatment of posttraumatic stress disorder ( PTSD ), a chronic and disabling condition. A study has evaluated the efficacy and saf ...


Depressive symptoms are common in schizophrenia and can worsen outcomes and increase suicide risk. Lurasidone ( latuda ) is an atypical antipsychotic agent indicated for the treatment of schizophrenia ...


Treatment of bipolar depression is complicated by variable response and risk of switch to mania. Guidance is informed by the strength of evidence rather than by comparative data. Researchers have p ...


Since the 1970s, clinicians have increasingly become more familiar with hyperprolactinemia ( HPRL ) as a common adverse effect of antipsychotic medication, which remains the cornerstone of pharmacolog ...


Since 1999, there has been a dramatic increase in opioid overdose deaths and addiction to opioid drugs, including both prescription opioid pain relievers and heroin. Increased rates of addiction hav ...


A study has determined, using research on Duloxetine ( Cymbalta ) for major depressive disorder as an example, if there are inconsistencies between protocols, clinical study reports, and main publicly ...


A study has investigated if the widely publicized warnings in 2003 from the FDA ( Food and Drug Administration ) about a possible increased risk of suicidality with antidepressant use in young people ...


In Sweden, a study has investigated the association between drug treatment for attention-deficit / hyperactivity disorder ( ADHD ) and risk of concomitant suicidal behaviour among patients with ADHD. ...


A systematic review and meta-analysis of observational studies has investigated the change in mental health after smoking cessation compared with continuing to smoke. Eligibility criteria were long ...


A systematic review and meta-analysis was performed on published and unpublished efficacy studies of Agomelatine in people with depression. The eligibility criteria were double blind randomised pla ...


Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. A study has determined efficacy and safety of Varenicline and Bupropion sustained-release ( SR; combinatio ...


A review on the efficacy and the tolerability of Quetiapine ( Seroquel ), either as monotherapy or combination therapy, for acute bipolar depression, was done. Researchers have included all randomi ...


Ketamine's efficacy in depressive disorders has been established in several controlled trials. The aim of a study was to determine whether or not Ketamine administration significantly improves depress ...