The aim of the study was to estimate the risk of fatal and non-fatal myocardial infarction and stroke in patients with bipolar I disorder compared to people without bipolar I disorder.
Utilizing a records-linkage system spanning 30 years ( 1966-1996 ), a population-based cohort of 334 subjects with bipolar I disorder and 334 age and sex-matched referents from Olmsted County, Minnesota, U.S. was identified.
Longitudinal follow-up continued until incident myocardial infarction or stroke ( confirmed by board-certified cardiologist / neurologist ), death, or study end date ( December 31, 2013 ).
There was an increased risk of fatal or non-fatal myocardial infarction or stroke ( as a composite outcome ) in patients with bipolar I disorder [ hazard ratio, HR 1.54, 95% confidence interval ( CI ) 1.02, 2.33; p=0.04 ].
However, after adjusting for baseline cardiovascular risk factors ( alcoholism, hypertension, diabetes, and smoking ), the risk was no longer significantly increased ( HR 1.19, 95% CI 0.76, 1.86; p=0.46 ).
This study in a geographically defined region in the U.S. has demonstrated a significant increased risk of myocardial infarction or stroke in bipolar I disorder, which was no longer significant after adjustment for cardiovascular risk factors. ( Xagena )
Prieto ML et al, J Affect Disord 2016;194:120-127