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Cytisine was superior to Nicotine replacement therapy in helping smokers quit smoking

Placebo-controlled trials indicate that Cytisine, a partial agonist that binds the nicotinic acetylcholine receptor and is used for smoking cessation, almost doubles the chances of quitting at 6 months.
Researchers investigated whether Cytisine was at least as effective as nicotine-replacement therapy in helping smokers to quit.

A pragmatic, open-label, noninferiority trial in New Zealand was conducted; 1310 adult daily smokers who were motivated to quit and called the national quitline were randomly assigned in a 1:1 ratio to receive Cytisine for 25 days or Nicotine replacement therapy for 8 weeks.

The primary outcome was self-reported continuous abstinence at 1 month.

At 1 month, continuous abstinence from smoking was reported for 40% of participants receiving Cytisine ( 264 of 655 ) and 31% of participants receiving Nicotine replacement therapy ( 203 of 655 ), for a difference of 9.3 percentage points ( 95% confidence interval, 4.2 to 14.5 ).

The effectiveness of Cytisine for continuous abstinence was superior to that of Nicotine replacement therapy at 1 week, 2 months, and 6 months.

In a prespecified subgroup analysis of the primary outcome, Cytisine was superior to Nicotine replacement therapy among women and noninferior among men.

Self-reported adverse events over 6 months occurred more frequently in the Cytisine group ( 288 events among 204 participants ) than in the group receiving Nicotine replacement therapy ( 174 events among 134 participants ); adverse events were primarily nausea and vomiting and sleep disorders.

In conclusion, when combined with brief behavioral support, Cytisine was found to be superior to Nicotine replacement therapy in helping smokers quit smoking, but it was associated with a higher frequency of self-reported adverse events. ( Xagena )

Walker N et al, N Engl J Med 2014; 371:2353-2362