Psychiatry Xagena

Potential association between hypomagnesaemia and depression

The reported risk of depression in patients with hypomagnesaemia is controversial.

The objective of a meta-analysis was to assess the association between depression and hypomagnesaemia.

Six observational studies ( three cohort studies, two cross-sectional studies and a case–control study ) with a total of 19 137 patients were identified and included in the data analysis.

The pooled risk ratio ( RR ) of depression in patients with hypomagnesaemia was 1.34 ( 95% CI, 1.01–1.79, I2 = 33% ).

The association between depression and hypomagnesaemia was marginally insignificant after the sensitivity analysis including only cohort and case–control studies, with a pooled RR of 1.38 ( 95% CI, 0.92–2.07, I2 = 24% ).

In conclusion, the study has demonstrated a potential association between hypomagnesaemia and depression.
Further studies assessing the benefits of treatment of hypomagnesaemia in patients with depression are needed. ( Xagena )

Cheungpasitporn W et al, Intern Med J 2015; 45: 436–440